Thursday, January 10, 2008

Getting Lucky

I have taken care of many many syncope cases. The routine is.

Observation
Telemetry
Echo
Orthostatics

Everything is normal and on they go. The most common diagnosis is that there is no diagnosis

Usually the basket diagnosis of vaso vagal syncope.

An old person trying to crap
A young person distraught over their break up.

Rarely is it seizure
Rarely is it stroke (I'd say just about never)
Rarely is it structural cardiac disease in the abscence of known cardiac disease
Rarely is it life threatening

If anything, my main concern is always cardiac arrhythmia. More so in a structurally abnormal heart or an abnormal EKG.

The history, more than anything drives the workup and diagnostic testing.

And it should.

In a recent case of mine, I think we got lucky.

A young patient was out on the town at a local sports bar. Not drunk. Living his life normal. The next thing he knows, he's on the ground with a bunch of people looking down at him.

He passed out. Medically, syncope.

His history was negative.

Very negative.

No pre aura. No post ictal. No cardiac. No pulmonary complaints. No head ache. No bowel or bladder dysfunction. No leg pain, cramping or swelling., No Chest pain. No cough. No shortness of breath. He does have a history of melanoma and is actively followed. A negative brain MRI 6 weeks ago. Nothing strikingly abnormal on basic panels. He does have a family history of aortic aneurysm, but he complains of no pain at all.

A transient event. A self limited event.

An unexplained event, like so often it is. Go home and live your life.

Labs OK
CXR OK
EKG OK
Echo OK, except for right ventricular pressure (RVP) of about 40.

It certainly peeked my curiosity on why a young nonsmoking man would have elevated pulmonary artery pressures.

My partner, who admitted the patient on the night shift was concerned about aneurysm of the aorta and ordered a CTA of the chest, catching both aneurysm eval and PE eval at the same time.

I had just finished giving my routine talk to syncope patients to him.

"If all these tests are negative, you go home."

I reviewed with the oncologist. No cardiac toxic chemo. My suspicion in this case was simply that it was a garden variety vaso vagal.

Until that Echo came back.

Elevated pulmonary pressures.

Normal O2 sats. No shortness of breath.

Could he infact have a pulmonary embolism? An asymptomatic (minus his syncope) PE?

While the suspicion for aortic aneurysm is low, the CTA had been ordered and in fact the patient was on his way to get it just after I saw him.

A little while later I get the call.

Pulmonary Embolism.

He certainly has the one risk factor that puts him at risk. Cancer. But that's it.

And that was his only presenting "complaint", which in actuality, is not even a complaint.

It is a part of his history.

In the end, I think a little bit of luck saved the day.

I must admit, a CT angiogram of the chest to evaluate for pulmonary embolism is not part of my routine evaluation for syncope, especially in a negative ROS.

The history drives the diagnosis.

Nothing on his history or physical, subjective or objective data pointed to pulmonary embolism.

Except that elevated pulmonary pressure.

Had my partner not ordered the chest CT, I think I may have.

If not for the only reason to settle my internal curiosity as to why a young man had elevated pulmonary pressures.


Had the patient been morbidly obese, the echo tech may not have been able to document RVP and I would have NO suspicion for PE.

I present this case history to any doctors out there reading this.

The often forgotten diagnosis of pulmonary embolism, a sometimes fatal condition, is usually only diagnosed when you think of it.

As a member of our hospital wide committee for the prevention of venous thromboembolism and a member of the Society of Hospital Medicine collaborative effort for the prevention of VTE, I find myself thinking of it often.

Regardless

I still think a little bit of luck played out here.
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9 Outbursts:

  1. Related:

    Pulmonary Embolism and Thoracic Aortic Dissection: Images

    http://clinicalcases.blogspot.com/2004/02/pulmonary-embolism-and-thoracic-aorta.html

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  2. A wise attending once told me long ago that PE is the single most over AND under-suspected inpatient diagnostic condition. Probably true.

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  3. Glad you both were able to help that pt.

    Interesting post and am enjoying the daily comics. :)

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  4. I'm actually surprised how often PE's present with syncope. I'm sure it occurs immediately after the embolism and the sudden fall in left atrial filling drops the cardiac output for a few seconds (and dropping the patient) until alternative vascular paths are recruited.

    The patient then wakes up and achieves some degree of "steady state" until his inquisitive hospitalist orders the right test.

    Kudos to you and your partner...even if some luck was involved!

    By the way, I've never successfully diagnosed a PE by cardiac ascultation before but I have used it to diagnose pulmonary HTN. Listen for a loud P2 (P2 is loud if you hear a split S2 anywhere outside the left sternal, second intercostal space. If you hear a split S2 at the apex, it's a dead giveaway). A widely split S2 also helps but these are awfully hard to discriminate in a loud E.R.!

    John

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  5. Good call. As a pathologist who has done some hearbreaking autopsies involving unsuspected PE's, it's nice to see one caught antemortem. I have only one question, was the patient overweight? And I gather the melanoma was of significant stage to have required chemo?

    The other most frequent unexpected autopsy finding in my experience was dissecting aortic aneurysm.

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  6. Same shift, two syncope patients.

    Patient #1: 50 man with syncope and brief LOC. Normal EKG, normal CXR, and vitals. Only tip off -- bilateral leg pain, ?weak pulses. Pissed that he was in the ER. Pissed that the CT scanner broke down while he was getting on it. Had to wait for TEE. DX: aortic dissection.

    Patient #2: 40 female with no identifiable risks with underlying "anxiety". PE,vitals, ekg, pulsox, everything normal. tip off: "A friend of a friend had a PE, do you think it could be that?" Me: "Ok we can screen for it" DX: PE.

    Tricky business and wasteful business looking through all the negetives to find these positives.

    PS. Have you seen much Brugada syndrome. There is growing awareness in the ER literature and I have picked up a case in the last year.

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  7. you picked up a real case of brugada or a brugada pattern on ekg?

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  8. Brugada pattern on EKG after a syncopal episode without other abnormalities, so I assumed cause and effect. Cardiology admitted for EP study. This was at a place fI work infrequently so did not get follow up.

    From what I understand the association between brugada pattern on ekg and syndrome is fairly high.

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  9. truthfully, i don't know what population you are talking about when you say association with brugada/ekg and syndrome being fairly high?
    brugada coved pattern or saddleback pattern?
    all other much more common causes of st elevation eliminated and a syncopal asian young man with family history of sca-prob true there is a high association, but how do we know for sure. but eps is unreliable in diagnosing brugada, genetic tests are not great. patients are recommended to have icd's, so just putting one in does not mean they had brugada. just to put a number to the pain, for patients with brugada pattern, the data shows eps has sn 66% and sp 34%. positive predictive value of eps was very low, even though individuals with positive test as a group had worse outcomes.

    from circ, things that cause brugada like pattern on ekg
    ------------------------
    Class IC drugs (flecainide, pilsicainide, propafenone)
    Class IA drugs (ajmaline, procainamide, disopyramide, cibenzoline)
    Lithium
    Calcium channel blockers
    Beta blockers
    Nitrates
    Nicorandil (a potassium channel opener)
    Psychotropic drugs
    Tricyclic antidepressants
    Amitriptyline
    Nortriptyline
    Desipramine
    Clomipramine
    Tetracyclic antidepressants
    Maprotiline
    Phenothiazines
    Perphenazine
    Cyamemazine
    Selective serotonin reuptake inhibitors
    Fluoxetine
    Other
    Dimenhydrinate
    Cocaine intoxication
    Alcohol intoxication
    Pacing, vagal maneuvers, and increased alpha-adrenergic tone

    that's probably more than you wanted to know. i struggle with brugada questions every month and i still don't know what to do with them. :)

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